Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels.
2 Medisch Centrum Buitenveldert, Amsterdam, The Netherlands.
3 Department of Internal Medicine and Endocrinology, Reinier de Graaf Groep of Hospitals, Delft-Voorburg, The Netherlands.
4 Department of Neuroscience, Section Anatomy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract
Treatment of paroxetine-induced penile anesthesia in Post SSRI Sexual Dysfunction
(PSSD) by Low-power Laser Irradiation (LPLI) is unknown in medical
literature. The aim of the current article is to report partial efficacy
of LPLI for paroxetine-induced persistent penile anesthesia. We report
on a male patient who presented with a history of reversible loss of
smell, taste and skin sensitivity occurring within a week after start of
20mg/day paroxetine-hemihydrate for a depressive period. Concurrently,
patient suffered from penile anesthesia, scrotum hypesthesia,
anejaculation and erectile difficulties with normal sexual desire.
During 2.5 years of paroxetine treatment and throughout 2 years after
paroxetine discontinuation, genital and sexual complaints persisted.
Penile anesthesia was treated by LPLI with single and multi diode pulsed
laser probes. After 20 LPLI-treatment sessions of 15min each, patient
reported partial return of penile touch and temperature sensation.
Clinical improvement of glans penis sensitivity was reported to 20% and
40%, compared to pre-paroxetine treatment penile sensitivity during
erect and flaccid states, respectively. However, anejaculation and
erectile difficulties remained unchanged. Briefly, in the current
patient with early onset of PSSD, LPLI treatment reduced
paroxetine-induced penile anesthesia. It is hypothesized that SSRI
treatment induces disturbances of transient receptor potential (TRP) ion
channels of mechano-, thermo- and chemosensitive nerve endings and
receptors resulting in the penile anesthesia in PSSD. It is further
hypothesized that there are two types of PSSD, one of which occurs soon
after the start of SSRI treatment.
Copyright © 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
KEYWORDS:
Low-power laser irradiation; Paroxetine; Penile anesthesia; Post SSRI sexual dysfunction; TRPV1; Transient receptor potential
- PMID:
- 25483212
- DOI:
- 10.1016/j.ejphar.2014.11.031
- [Indexed for MEDLINE]
- LINK: http://www.ncbi.nlm.nih.gov/pubmed/25483212
