SSRIs and persistent sexual dysfunction Introduction The serotonin reuptake inhibitors (SSRIs) are indicated for the treatment of major depressive disorder, social anxiety disorder, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, and posttraumatic stress disorder [1- 7]. SSRIs available on the Dutch market are citalopram (Cipramil® ), escitalopram (Lexapro® ), fluoxetine (Prozac® ), fluvoxamine (Fevarin® ), paroxetine (Seroxat® ), and sertraline (Zoloft® ). Venlafaxine (Efexor® ) in a dosage less than 150 mg is also considered an SSRI [8].
Sexual dysfunction is a known side effect of SSRI treatment. SSRIs are associated with decreased libido, erectile dysfunction, ejaculatory disturbances, delayed orgasm and anorgasmia [1-7]. These dysfunctions typically endure for as long as the medication is taken and it has generally been assumed that these effects would resolve upon discontinuation of treatment. However, there is emerging evidence that in some individuals sexual dysfunction is persistent after cessation of SSRIs.
FULL TEXT: https://databankws.lareb.nl/Downloads/KWB_2012_3_SSRI.pdf
