Riv Psichiatr. 2018 Mar-Apr;53(2):95-99. doi: 10.1708/2891.29158.
The Diagnostic clinical Interview for Drug Withdrawal 1 (DID-W1) – New Symptoms of Selective Serotonin Reuptake Inhibitors (SSRI) or Serotonin Norepinephrine Reuptake Inhibitors (SNRI): inter-rater reliability
- 1
- Department of Health Sciences, University of Florence, Italy - Department of Psychiatry & Neuropsychology, Maastricht University, The Netherlands.
- 2
- Clinical Psychopharmacology and Therapeutics Unit, Montréal, Québec, Canada - University Mental Health Institute of Montreal, Research Center Fernand Seguin, University of Montréal, Québec, Canada.
- 3
- Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, USA.
- 4
- Department of Psychology, University of Bologna, Italy - State University of New York at Buffalo, Buffalo, New York, USA.
Abstract
AIM:
A wide range of clinical phenomena have been reported with dose reduction or drug discontinuation of Selective SerotoninReuptake Inhibitors (SSRIs) or Serotonin Norepinephrine Reuptake Inhibitors (SNRIs). In 2015, a new classification of SRIs/SNRIs withdrawal (i.e., new withdrawal symptoms, rebound symptoms withdrawal, persistent post-withdrawal disorders) was outlined on the basis of the literature and clinical observations. A semistructured clinical interview, the Diagnostic clinical Interview for Drug Withdrawal 1 - New Symptoms of SSRI and SNRI (DID-W1), was developed for identifying and differentiating such syndromes. Its inter-rater reliability has been tested.
METHODS:
Seventeen consecutive outpatients with a history of SSRI or SNRI dose reduction or discontinuation were assessed independently by 2 clinicians at different times during the same day. Percent agreement, Cohen’s kappa, and the squared correlation coefficient were used to measure inter-rater reliability.
RESULTS:
The percent agreement for the whole interview was 97.06%, the Cohen’s kappa 0.85 (95% CI of 0.61-1.08), the squared correlation coefficient 0.72.
DISCUSSION AND CONCLUSIONS:
The kappa values indicated excellent inter-rater agreement. Validity evaluation and comparison with other instruments need to be performed. The DID-W1 may help diagnosing the clinical phenomena related to SSRI and SNRI discontinuation, their differentiation from relapse, and the potential iatrogenic origin of psychiatric symptoms in clinical practice.
- PMID:
- 29674777
- DOI:
- 10.1708/2891.29158
FULL TEXT: http://www.rivistadipsichiatria.it/articoli.php?archivio=yes&vol_id=2891&id=29158
